Research. Education. Treatment.

We understand headaches affect you as well as your health, daily activities, and your loved ones. We are passionate about the need for additional headache research, and we're working hard to make the Headache Center part of the solution. 

Joining a clinical trial may offer a potential option that might be unavailable otherwise. To help researchers develop new and better treatments, we are participating in clinical trials for teens and adults suffering from a variety of headache and migraine disorders. Most clinical studies offer compensation for time and travel; and the visits and treatment are free of charge. 

Most clinical trial studies have adjusted their protocols to reduce their in-person visits and now allow telehealth and virtual appointments to protect everyone's health.  Learn more about how we are fighting COVID-19.

Clinical Studies at a Glance

Episodic Migraine Study

° Adults 18-50 years old with High Frequency Episodic Migraines

° Study duration: 6.5 Months 

° Use of eDiary

° Investigation drug: 4 injections study drug vs. placebo 

° Compensation: Up to $400

Observational Migraine Study 

° Adults 18+ with Chronic Migraines

° Study duration: 2 Years

° Access to web portal to complete questionnaires

° No investigational drug

° All visits can be completed over the phone

° Compensation: Up to $150

Pediatric Migraine Study 

° Children 12-17 years old with Moderate to Severe Migraines

° Study Duration: 3.5 months

° Investigational drug: lasmiditan vs. placebo

° Compensation: Up to $225

° If completed, patient can enroll on part 2: PEDS2:

- Different doses of lasmiditan. No placebo

- Duration: 1 year

- Compensation: up to $ 575

Below is a list of the clinical trials we are currently conducting. If you do not see a Clinical Study for your condition, please contact us to learn about other options. 

In children and adolescents, headaches and migraines usually result in missed school days, poorer academic performance, and a negative impact on their quality of life. There are few treatments approved to treat migraines in adolescents, and only one treatment is approved for children aged 12 to 18. 

For pediatric studies, we are looking for children and teenagers ages 12 to less than 18 who have had a history of migraine headaches for more than six months.  Below are our ongoing trials. The following links will take you to the official website for clinical trials (clinicaltrials.gov) and will provide you with more information about each study.

A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS1)

A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS2)

There is compensation for your participation, and the treatment will be free of charge.

Episodic migraine (EM) patients experience up to 14 headache days per month. For many sufferers medication overuse is the most common reason why episodic migraine turns chronic, significantly diminishing their quality of life.

We are currently looking for patients who are 18 years old or older who have a history of migraine in the past 12 months. Patients should experience at least 4 migraine attacks per month.   Below are our ongoing trials. The following links will take you to the official website for clinical trials (clinicaltrials.gov) and will provide you with more information about each study. 

Erenumab - Comprehensive Assessment of Efficacy in (High-Frequency) Episodic Migraine (EMBRACE)

There is compensation for your participation, and the treatment will be free of charge. 

Migraine is associated with several multiple disorders that significantly diminish the quality of life of patients. Migraine is often linked with psychiatric disorders, sleep disorders, fatigue, cardiovascular risk factors, and cardiovascular and cerebrovascular diseases. Observational studies are needed to confirm the real-world effectiveness of migraine headache treatments. 

We are currently looking for patients who are 18 years old or older who are switching or initiating new preventive treatment.  Below are our ongoing trials. The following links will take you to the official website for the respective clinical trial and will provide you with more information about each study.  

Preventive Treatment of Migraine: Outcomes for Patients in Real-World Healthcare Systems (TRIUMPH)

 There is compensation for your participation.

Choosing to participate in a clinical trial is an important personal decision. Visit our Clinical Study FAQs for more information.